![]() The images were obtained using a dedicated PET/CT scanner (Discovery VCT ®, GE medical systems, Milwaukee WI, USA) 40–60 min after intravenous injection of 3.75–5.55 MBq/kg of 18F-FDG. Positron emission tomography Image acquisitionĪll patients fasted for at least 6 h before PET/CT examination. All the patients read and signed the informed consent form. This study was approved by the ethics committee of Tongji medical college of Huazhong university of science and technology. Ethics approval and consent to participate Statistical analyses were done using Graph pad prism version 7.04. Statistical analysisīaseline patient characteristics were summarized. Study typeĭescriptive cross-sectional study. 2 were control without any symptoms, no history of hypertension, diabetes mellitus or coronary artery disease, there ECG and CAG were normal. We assessed 12 patients admitted at department of cardiology, Wuhan union hospital, 10 who presented with typical angina symptoms and had a typical history of chest pain, ST-changes on EKG with normal coronary arteries on coronary angiography. Most of the studies were done to study the epicardial coronary artery vessels and less focus on microvascular coronary vessels, that’s why we had to do this study. Coronary flow reserve calculated as a ratio of hyperaemic to rest absolute myocardial blood flow (MBF) is a measure of coronary vasomotor dysfunction that integrates the hemodynamic effects of epicardial coronary stenosis, diffuse atherosclerosis, and microvascular dysfunction on myocardial tissue perfusion. Diffuse coronary atherosclerosis is highly prevalent among patients with known or suspected coronary artery disease, increases the severity of inducible myocardial ischemia (beyond the effects of epicardial coronary obstruction), and identifies patients at high risk for serious adverse events, including cardiac death. The coronary flow reserve (CFR) is a well validated index that allows the assessment of blood flow impairment originating from obstructive, diffuse, or microcirculatory involvement of the coronary circulation. Our findings indicate PET/CT coronary flow reserve concept provides a platform for the diagnosis of non-obstructive coronary artery disease in patients with signs and symptoms of ischemia without angiographic obstructive CAD.Ĭoronary flow reserve (CFR), is an integrated measure of focal, diffuse, and small vessel coronary artery disease, can also be explained as a calculated ratio of hyperaemic to rest absolute myocardial blood flow. On further investigation by Positron emission tomography/CT we found out 58% had abnormal CFR and 42% had normal coronary flow reserve. All patients and controls had normal coronaries on coronary angiography TIMI 3 flow. About 83% had ST segment and T wave changes on ECG. 83% were males and 17% females, more patients had hypertension about 50%, few had diabetes mellitus about 16%, while those with both hypertension and diabetes mellitus were 17%. In our study 92% were between 41 and 60 years. We also aimed at knowing the significance of PET in diagnosing coronary microvascular disease. Non-obstructive coronary artery disease is defined as atherosclerotic plaque that does not obstruct blood flow or result in anginal symptoms. To improve current knowledge of coronary flow reserve and non-obstructive coronary artery disease in terms of definition, features and clinical implications of measurement of coronary flow reserve (CFR), is an integrated measure of focal, diffuse, and small vessel coronary artery disease, can also be explained as a calculated ratio of hyperaemic to rest absolute myocardial blood flow. ![]()
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